Melissa Nelson Selected Research

EC145

12/2018	Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic.
1/2016	High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.
4/2014	Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs.
3/2014	Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.
2/2011	Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.

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Melissa Nelson Research Topics

Disease

11	Neoplasms (Cancer) 01/2020 - 02/2011
3	Pain (Aches) 01/2021 - 11/2019
1	Eosinophilic Esophagitis 01/2021
1	Esophageal Achalasia (Megaesophagus) 01/2021
1	Respiratory Insufficiency (Respiratory Failure) 01/2021
1	Substance-Related Disorders (Drug Abuse) 01/2021
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Osteosarcoma (Osteogenic Sarcoma) 01/2019
1	Weight Loss (Weight Reduction) 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Chronic Disease (Chronic Diseases) 09/2018
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Constipation 02/2011
1	Erectile Dysfunction 02/2009

Drug/Important Bio-Agent (IBA)

8	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 02/2011
7	Pharmaceutical PreparationsIBA 01/2020 - 01/2016
5	AlkaloidsIBA 01/2021 - 02/2011
5	EC145IBA 12/2018 - 02/2011
2	Biomarkers (Surrogate Marker)IBA 11/2019 - 01/2019
2	tubulysin BIBA 01/2019 - 04/2016
2	HydrazinesIBA 04/2016 - 01/2016
1	Proton Pumps (Proton Pump)IBA 01/2021
1	CalciumIBA 01/2021
1	CytokinesIBA 01/2021
1	Chemokine CCL26IBA 01/2021
1	Tryptases (Tryptase)IBA 01/2021
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 01/2021
1	mitragynineIBA 01/2021
1	ArrestinIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	AntigensIBA 01/2019
1	isothiocyanic acidIBA 01/2019
1	Chimeric Antigen ReceptorsIBA 01/2019
1	Docetaxel (Taxotere)FDA Link 01/2019
1	Biological ProductsIBA 01/2019
1	LigandsIBA 01/2019
1	Fluorescein-5-isothiocyanate (FITC)IBA 01/2019
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2018
1	Cisplatin (Platino)FDA LinkGeneric 12/2018
1	HydrazonesIBA 04/2016
1	Alanine (L-Alanine)FDA Link 04/2016
1	AcetoneIBA 04/2016
1	BuffersIBA 04/2016
1	Acetic Acid (Vinegar)FDA LinkGeneric 04/2016
1	Antineoplastic Agents (Antineoplastics)IBA 04/2016
1	Mannitol (Osmitrol)FDA LinkGeneric 04/2016
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2016
1	EC 0489IBA 02/2011
1	Alprostadil (Muse)FDA LinkGeneric 02/2009

Therapy/Procedure

7	Therapeutics 01/2021 - 03/2014
1	Heller Myotomy 01/2021
1	Self Medication 01/2021
1	Analgesia 01/2021
1	Drug Therapy (Chemotherapy) 01/2019